Inter's midfield heartbeat. A player who reads the game like few others, the Argentina international offers protection to the defence and thrust in attack with his probing runs and neat distribution. Is widely regarded as one of the most intelligent players in Serie A. At youth and senior level for club and country, Cambiasso has won over twenty titles in his career. His previous clubs are Independiente, River Plate and Real Madrid.

Early career
Cambiasso started his professional career with Argentinos Juniors in 1995, moving to Real Madrid in 1996. In 1998, he moved back to Argentina, where he played for three years with Independiente and one with River Plate. During this time, he earned his nickname "Egg in a bun." With some good experience under his belt, he returned to Real Madrid in 2002. He helped Los Blancos win the UEFA Super Cup, La Liga, and the Intercontinental Cup in 2002 and the Spanish SuperCup in 2003.

Internazionale
In July 2004, Cambiasso signed with Internazionale in Milan after his contract with Real Madrid expired in June 2004. He helped Internazionale win the Italian Cup in his first season with the club, playing regularly as a defensive midfielder, partnered in the middle of Inter's midfield with fellow Argentine Juan Sebastián Verón. In Italy, he became known as one of the outstanding players of the 2004–05 season, along with Milan's Kaká.

During the return match for the final of the 2006 Coppa Italia, Cambiasso scored an impressive goal, the first of the match, for the 3–1 victory over Roma. On 30 September 2006, he scored twice in the opening game of the season, with Inter defeating Fiorentina 3–2. On 7 November 2007, he along with Zlatan Ibrahimović scored a brace a piece to defeat CSKA Moscow 4–2 in the Champions League. On 23 March 2009, it was announced that Inter and Cambiasso had come to terms about a contract renewal which expires in 2014.

He was very important in the 2010 Champions League win as well, scoring the second goal of a 2–1 victory over Chelsea at the San Siro, a result which ultimately saw Inter go on to win the tournament.