Luigi Sepe is an Italian professional footballer who plays for Parma, on loan from Napoli as a goalkeeper.

Born in Torre del Greco, the Province of Naples, Sepe made his debut for his hometown club in Serie A on 28 January 2009, at age of 17, during the match against Fiorentina, lost 2–1. He replaced Gianello in the 32nd minute. He wore the number 44 jersey during the 2008–09 season. He was the fourth keeper behind Gennaro Iezzo, Nicolás Navarro and Matteo Gianello.

In 2010–11 season, he was named in 2010–11 UEFA Europa League as list B member (U21 youth product), which he was the fourth keeper behind Morgan De Sanctis, Iezzo and Gianello.

On 10 July 2018, Sepe signed with Parma On loan until 30 June 2019.

Sepe started three out of four matches for the Italy U18 team at the U18 Slovakia International Cup, ahead if Valerio Frasca in April 2009. Sepe made successive appearances with the Italy U19 team (born 1991 or later) from March to September in 2009. In both appearances, he replaced Simone Colombi for the second half, including versus Ukraine (born 1990 or later team). He was the reserve keeper for Colombi at the 2010 UEFA European Under-19 Football Championship qualification, and he also played once. After Italy qualified to the next round, he did not receive any call-ups again.