Seko Mohamed Fofana is an Ivorian professional footballer who plays as a midfielder for French club Lens in Ligue 1.

Born in Paris, France, Fofana began his youth career at Paris when he was nine and stayed there for six years before joining Lorient. After two years at Lorient, he moved to England when he joined Premier League side Manchester City in 2013 and was immediately sent to the development squad. On 27 November 2014, Fofana signed for Championship side Fulham on loan until 31 January 2015. After making two appearances for City during their pre-season tour in Australia (playing the second half of a 2–0 win over Adelaide United, and coming on as a late substitute in Manchester City's 1–0 win over Melbourne City), the Premier League club agreed to send Fofana out on loan again to gain further experience. The Frenchman subsequently returned to his native France, to join Bastia on a season-long loan on 29 July 2015. After three years at Manchester City, Fofana joined Serie A side Udinese, signing a five-year deal.

Fofana previously represented France U16, France U17, France U18 and France U19. On 3 April 2017, Fofana chose to represent the Ivory Coast, the country of his parents. Fofana made his debut for Ivory Coast in a 2–0 2018 FIFA World Cup qualification loss to Morocco on 11 November 2017.