Matías Agustín Silvestre (born 25 September 1984 in Mercedes, Buenos Aires) is an Argentine footballer who plays for Internazionale in the Italian Serie A on loan from Palermo.

Boca Juniors
Silvestre began his career with Argentinean club, Boca Juniors, where he would go on to make his league debut on 23 March 2003, in a 3–1 win over C.A. Lanús. Silvestre soon was inserted into the Boca Juniors starting line-up and between 2003 and 2007, he went on to make 63 league appearances, scoring six goals. He was used as both a central defender and a right full back, during his spell with the club. Following an impressive 2007 season, Silvestre was transferred to Calcio Catania in the Italian Serie A.

Calcio Catania
During the 2008 January transfer window, Silvestre transferred to Sicilian club Calcio Catania on loan. His first six months at Catania was not so great as he was not part of then-coach Silvio Baldini's starting team, making just 11 appearances, just five as a starter. His loan, however, was made permanent in the summer of 2008, after Walter Zenga was appointed head coach, following the sacking of Baldini. He soon became an instrumental part of Catania's first team and was a major influence on their fairly successful 2008–09 season, as the club avoided relegation for the third consecutive season. Silvestre continued to shine during his third season in Sicily as the defender went on to make more appearances than any of his temmates during the 2009–10 campaign.

He formed a solid defensive line-up with the likes of Pablo Álvarez, Nicolás Spolli, Christian Terlizzi, and Ciro Capuano as Catania recorded their record breaking points total in Serie A, finishing in 13th place with just 45 goals conceded in 38 games. During the 2010-11 Serie A campaign, Silvestre earned captaincy at the Sicilian club, following the sale of Giuseppe Mascara to Napoli on 31 January 2011. He has made 116 total appearances for his club, scoring seven goals, six of which have come during the 2010-11 Serie A season, a season which recorded a third consecutive record points total for the Sicilian club. On July 9, 2011, Marco Biagianti was assigned captaincy of the club for the 2011-12 Serie A season.

Palermo
On 9 August 2011, he moved to Palermo for €7,3M. He debuted in rosanero the September 11, 2011 in the 4-3 victory against Inter.

Internazionale
On 6 July 2012, he was officially loaned to Internazionale.