Simone Missiroli is an Italian footballer who plays for SPAL as a midfielder.

Reggina
A native of Reggio Calabria, he made his Serie A debut with the local team Reggina on 24 April 2005 against Brescia Calcio. He also spent the 2008–09 season on loan at Treviso, and returned to Reggina to help his hometown club in their 2009–10 Serie B campaign. In January 2011 he left for Cagliari in a temporary deal for €1 million.

Sassuolo
On 4 January 2012, Missiroli moved to Serie B side U.S. Sassuolo Calcio for €3.5 million. Before leaving Reggina, Missiroli was one of the team topscorers of the 2011–12 season as a playmaker. Missiroli was also named the captain of the team, wearing the armband on several occasions, such as the game against Sassuolo.

On 11 January 2016, he signed a new 4½ year contract with Sassuolo.

SPAL
On 17 August 2018, Missiroli signed with Serie A club SPAL.