Djamel Eddine Mesbah is an Algerian professional footballer who plays as a left back for the Italian Serie A club A.C. Milan.

An Algerian international, Mesbah was a member of the Algeria national team at the 2010 FIFA World Cup in South Africa.

On 18 January 2012, US Lecce announced that Mesbah would be leaving the club to join A.C. Milan. The following day, Milan confirmed the transfer, announcing that Mesbah had signed a four and a half year contract with the club for an undisclosed fee. On January 26, 2012, Mesbah made his debut for Milan, starting in the 2011–12 Coppa Italia quarter-final tie against Lazio. Mesbah played the entire match with Milan going on to win 3-1. On March 20, 2012, Mesbah scored his first goal for Milan, in a 2-2 draw with Juventus in the Semi-Finals of the 2011-12 Coppa Italia. His goal tied the game 1-1, but proved ineffective as Milan drew in extra time to exit the cup on aggregate 4-3.