Diego Alfredo "Tota" Lugano Moreno (born November 2, 1980 in Canelones) is a Uruguayan footballer who currently plays for Paris Saint-Germain and the Uruguay national football team as a central defender. Lugano has previously played for Plaza Colonia, Nacional, São Paulo and Fenerbahçe. He is also captain of the Uruguayan national football team, and was selected the best captain in the 2010 FIFA World Cup.

São Paulo
Diego Lugano came to São Paulo in 2003. He was contracted by president of the tricolor in that time, Marcelo Portugal Gouveia, without consulting the coach of club, Oswaldo de Oliveira, and, for this, he was known as "homem do presidente" (president's man). After Oliveira left the club, in late 2003, Lugano started playing matches more frequently. In 2005, while playing for São Paulo as a centre-back, he led the team to titles in the Campeonato Paulista, the Copa Libertadores, and the FIFA Club World Championship in Japan. That same year, Lugano was recognized as South America's best defender. His leadership skills and his willingness to fight for ball possession have raised his profile amongst São Paulo's supporters, where he is still highly regarded. Lugano has also mentioned that he still maintains a good relationship with the club. In 2006, he helped his club to the runner-up stage of the Copa Libertadores.

Fenerbahçe SK
Lugano joined Fenerbahçe on 21 August 2006 for a reported €7.5 million and signed a 3+1 year contract. He and former teammate Edu Dracena's powerful defensive abilities helped Fenerbahçe win the league during the club's 100th anniversary year. He is notorious for his presence in attack, as was shown with Previous club Fenerbahçe, having scored goals with headers from dead ball situations and support of the forward line. He became a fan favorite with his defensice tenacity and spectacular dead ball goals. Supporters refer to him as 'TOTA' (Talento, Orgullo, Tecnico, Ambicion - Talent, Pride, Skillfulness, Ambition in Spanish). Following a red card, he was suspended for 5 weeks after the derby match against Galatasaray during the 2008–09 season when he beat Emre Aşık on 12 April 2009 in Ali Sami Yen Stadium. Since then he has a strong connection with supporters, especially with the Genç Fenerbahçeliler. He was one of the captains of the team. He signed a new 4-year contract in 2009 with Fenerbahçe.

Paris Saint-Germain
On August 27, 2011 Fenerbahçe announced Lugano was leaving the club to join Paris-Saint Germain for a fee worth €3 million. However, his first season in France ended poorly and Lugano made just 12 appearances, mostly being cut out of the side due to injury and poor form.